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Publication Detail
Incobotulinumtoxin a for sialorrhea in neurological disorders: A real-life experience
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Martínez-Poles J, Nedkova-Hristova V, Escribano-Paredes JB, García-Madrona S, Natera-Villalba E, Estévez-Fraga C, López-Sendón Moreno JL, Avilés-Olmos I, Díaz GS, Martínez Castrillo JC, Alonso-Canovas A
  • Publication date:
    01/06/2018
  • Journal:
    Toxins
  • Volume:
    10
  • Issue:
    6
  • Status:
    Published
Abstract
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Botulinum toxin type A is one of the most useful treatments of sialorrhea in neurological disorders. Evidence for the use of incobotulinumtoxin A (inco-A) in the treatment of sialorrhea is limited. Thirty-six patients with sialorrhea were treated with infiltrations of inco-A into both parotid glands. The severity of sialorrhea was evaluated by the Drooling Severity Scale (DSS), and the Drooling Frequency Scale (DFS). Patients’ perceptions of clinical benefit were recorded via the Patient Global Impression of Improvement (PGI-I) scale. Following treatment, there was a significant difference in both the DFS and the DSS (p < 0.001). Clinical benefits on the basis of the PGI-I were present in up to 90% of patients.
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