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Publication Detail
Redistribution of Adhesive Forces through Src/FAK Drives Contact Inhibition of Locomotion in Neural Crest
Abstract
© 2018 The Authors Contact inhibition of locomotion is defined as the behavior of cells to cease migrating in their former direction after colliding with another cell. It has been implicated in multiple developmental processes and its absence has been linked to cancer invasion. Cellular forces are thought to govern this process; however, the exact role of traction through cell-matrix adhesions and tension through cell-cell adhesions during contact inhibition of locomotion remains unknown. Here we use neural crest cells to address this and show that cell-matrix adhesions are rapidly disassembled at the contact between two cells upon collision. This disassembly is dependent upon the formation of N-cadherin-based cell-cell adhesions and driven by Src and FAK activity. We demonstrate that the loss of cell-matrix adhesions near the contact leads to a buildup of tension across the cell-cell contact, a step that is essential to drive cell-cell separation after collision. Contact inhibition of locomotion leads to cell separation when they collide during migration. Roycroft et al. examine the role of mechanical force in cell separation and demonstrate that immediately after collision, cell-matrix adhesions are disassembled, leading to a tension buildup across cell-cell contacts that is essential for cell separation.
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London Centre for Nanotechnology
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Cell & Developmental Biology
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