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Publication Detail
Cytokine-Producing Effector B Cells
B cells are a heterogeneous population of cells that can contribute to immune responses by producing antibody, presenting antigen to T cells, and via the provision of soluble factors including cytokines. Although one of the lesser known functions of B cells, it is well documented that B cells can produce a vast array of cytokines, including both pro-and anti-inflammatory cytokines such as IFNγ, IL-12, TNF, IL-6, IL-2, IL-4, and IL-13, and immune-regulatory cytokines such as IL-10 and TGFγ. Based on the production of these cytokines, B cells can be partitioned into distinct 'effector' and 'regulatory' subtypes. In this article, we will discuss the identification, induction, and function of both effector and regulatory B cells in mouse and human.
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