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Publication Detail
Cervical dystonia: Normal auditory mismatch negativity and abnormal somatosensory mismatch negativity
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Chen JC, Macerollo A, Sadnicka A, Lu MK, Tsai CH, Korlipara P, Bhatia K, Rothwell JC, Edwards MJ
  • Publisher:
    Elsevier
  • Publication date:
    01/09/2018
  • Pagination:
    1947, 1954
  • Journal:
    Clinical Neurophysiology
  • Volume:
    129
  • Issue:
    9
  • Status:
    Published
  • Print ISSN:
    1388-2457
  • Language:
    English
  • Keywords:
    Mismatch negativity (MMN), Dystonia, Somatosensory integration
Abstract
OBJECTIVE: Previous electrophysiological and psychophysical tests have suggested that somatosensory integration is abnormal in dystonia. Here, we hypothesised that this abnormality could relate to a more general deficit in pre-attentive error/deviant detection in patients with dystonia. We therefore tested patients with dystonia and healthy subjects using a mismatch negativity paradigm (MMN), where evoked potentials generated in response to a standard repeated stimulus are subtracted from the responses to a rare “odd ball” stimulus. METHODS: We assessed MMN for somatosensory and auditory stimuli in patients with cervical dystonia and healthy age matched controls. RESULTS: We found a significant group ∗ oddball type interaction effect (F (1, 34) = 4.5, p = 0.04, ρ₁ = 0.63). A follow up independent t-test for sMMN data, showed a smaller sMMN amplitude in dystonic patients compared to controls (mean difference control-dystonia: −1.0 µV ± 0.3, p < 0.00, t = −3.1). However the amplitude of aMMN did not differ between groups (mean difference control-dystonia: −0.2 µV ± 0.2, p = 0.24, t = −1.2). We found a positive correlation between somatosensory MMN and somatosensory temporal discrimination threshold.CONCLUSION: These results suggest that pre-attentive error/deviant detection, specifically in the somatosensory domain, is abnormal in dystonia. This could underlie some previously reported electrophysiological and psychophysical abnormalities of somatosensory integration in dystonia. SIGNIFICANCE: One could hypothesize a deficit in pre-conscious orientation towards potentially salient signals might lead to a more conservative threshold for decision-making in dystonia.
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