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Publication Detail
Serendipitous evidence of T lymphocyte activation in close female relatives of patients with systemic lupus erythematosus.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Green MRJ, Kennell ASM, Larche MJ, Seifert MH, Isenberg DA, Salaman MR
  • Publication date:
    07/2009
  • Pagination:
    35, 39
  • Journal:
    Clin Exp Immunol
  • Volume:
    157
  • Issue:
    1
  • Status:
    Published
  • Country:
    England
  • PII:
    CEI3938
  • Language:
    eng
  • Keywords:
    Adult, Autoimmunity, Biomarkers, CD3 Complex, Case-Control Studies, Female, Flow Cytometry, Humans, Immunoglobulin G, Immunoglobulin M, Lupus Erythematosus, Systemic, Lymphocyte Activation, Male, Sex Distribution, Siblings, Statistics, Nonparametric, T-Lymphocytes
Abstract
A well-recognized characteristic of the autoimmune disease, systemic lupus erythematosus (SLE), is the high level of activated T cells present in the blood. Because of the increased size and granularity of activated T cells, in flow cytometry one might expect to find increased numbers of cells falling outside a standard light-scatter lymphocyte gate, and indeed we now report that the percentage of T lymphocytes in the gate (% TiG) was below the normal range in 23 of 58 (40%) female patients because of increased scatter values. However, the surprising additional observation was made that 18 of 30 (60%) female first-degree relatives of the patients also fell below the normal % TiG range, suggesting the presence of T cell activation in these relatives. This view is strengthened by the strong inverse correlation between plasma total immunoglobulin G(IgG), which was raised in some relatives, and % TiG, as T cell activation is a requirement for IgG production. Conversely, there was no correlation with IgM, which has no comparable link with T cell activation. While a definitive interpretation must await the demonstration of activation antigen expression in relatives, these findings suggest the existence of a T cell activation trait, not harmful in itself, which, however, contributes to the development of disease in patients with SLE.
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