UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data shown on the profile page to:

http://www.ucl.ac.uk/finance/secure/research/post_award
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
A spindle assembly checkpoint protein functions in prophase I arrest and prometaphase progression.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Homer H, Gui L, Carroll J
  • Publication date:
    13/11/2009
  • Pagination:
    991, 994
  • Journal:
    Science
  • Volume:
    326
  • Issue:
    5955
  • Country:
    United States
  • PII:
    326/5955/991
  • Language:
    eng
  • Keywords:
    Anaphase-Promoting Complex-Cyclosome, Animals, Carrier Proteins, Cdc20 Proteins, Cdh1 Proteins, Cell Cycle Proteins, Cyclin B1, Female, Gene Silencing, Meiosis, Meiotic Prophase I, Mice, Oocytes, Prometaphase, Protein-Serine-Threonine Kinases, Securin, Ubiquitin-Protein Ligase Complexes
  • Notes:
    PMCID: PMC3428834
Abstract
Two critical stages of mammalian oocyte regulation are prophase I arrest, which is important for sustaining the oocyte pool, and the progression through meiosis I (MI) to produce fertilizable eggs. We have found that the spindle assembly checkpoint protein BubR1 regulates both stages in mouse oocytes. We show that oocytes depleted of BubR1 cannot sustain prophase I arrest and readily undergo germinal vesicle breakdown, a marker for reentry into MI. BubR1-depleted oocytes then arrest before completing MI, marked by failure of polar body extrusion. Both meiotic defects in BubR1-depleted oocytes are due to reduced activity of the master regulator known as the anaphase-promoting complex (APC), brought about through diminished levels of the APC coactivator Cdh1.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Authors
Cell & Developmental Biology
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by