UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Transient structural variations alter gene expression and quantitative traits in Schizosaccharomyces pombe.
  • Publication Type:
    Working discussion paper
  • Authors:
    Jeffares DC, Jolly C, Hoti M, Speed D, Rallis C, Shaw L, Balloux F, Dessimoz C, Bahler J, Sedlazeck F
  • Publication date:
    13/04/2016
  • Status:
    Published
Abstract
The effects of structural variants on phenotypic diversity and evolution are poorly understood. We recently described the genetic and phenotypic variation among fission yeast strains and showed that genome-wide association studies are informative in this model. Here we extend this work by systematically identifying structural variations and investigating their consequences. We establish a curated catalog of copy number variants (CNVs) and rearrangements, including inversions and translocations. We find that SVs frequently vary within clonal populations and are weakly tagged by SNPs, consistent with rapid turnover. We show that CNVs produce measurable effects on gene expression both within and outside the duplicated regions. CNVs contribute to quantitative traits such as cell shape, cell growth under diverse conditions, sugar utilization in winemaking and antibiotic resistance, whereas rearrangements are strongly associated with reproductive isolation. Collectively, these findings have broad implications for evolution and for our understanding of quantitative traits and complex human diseases.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Genetics, Evolution & Environment
Author
Genetics, Evolution & Environment
Author
Genetics, Evolution & Environment
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by