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Publication Detail
Studies of a common idiotype PR4 in autoimmune rheumatic disease.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Williams W, Zumla A, Behrens R, Locniskar M, Voller A, McAdam KP, Isenberg DA
  • Publication date:
  • Pagination:
    1097, 1104
  • Journal:
    Arthritis Rheum
  • Volume:
  • Issue:
  • Status:
  • Country:
    United States
  • Print ISSN:
  • Language:
  • Keywords:
    Antibodies, Anti-Idiotypic, Antigens, Bacterial, Arthritis, Rheumatoid, Autoimmune Diseases, DNA, DNA, Single-Stranded, Enzyme-Linked Immunosorbent Assay, Humans, Immunoglobulin Idiotypes, Immunoglobulins, Lupus Erythematosus, Systemic, Mycobacterium leprae, Reference Values, Rheumatic Diseases, Severity of Illness Index, Sjogren's Syndrome
A new common idiotype, designated PR4, is described. This idiotype was originally identified on a human hybridoma-derived monoclonal antibody from a patient with leprosy, which binds the major Mycobacterium leprae-derived antigen, phenolic glycolipid-1, poly(ADP)-ribose, DNA, and poly(dT). The PR4 idiotype was found in patients with systemic lupus erythematosus (SLE) (70%), rheumatoid arthritis (40%), and Sjögren's syndrome (15%). It was not, however, found in the spouses of the SLE patients or (unlike other lupus idiotypes) in their healthy first-degree relatives. Although no correlation between PR4 idiotype levels and disease activity in SLE was found, a subset of rheumatoid arthritis patients with high levels of the idiotype was identified.
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