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Publication Detail
Analysis of immunoglobulin variable region genes of a human IgM anti-myeloperoxidase antibody derived from a patient with vasculitis.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Longhurst C, Ehrenstein MR, Leaker B, Stevenson FK, Spellerberg M, Chapman C, Latchmen D, Isenberg DA, Cambridge G
  • Publication date:
  • Pagination:
    334, 338
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  • Keywords:
    Adult, Aged, Amino Acid Sequence, Antibodies, Monoclonal, Autoantibodies, Base Sequence, Female, Genes, Immunoglobulin, Humans, Immunoglobulin Idiotypes, Immunoglobulin M, Immunoglobulin Variable Region, Male, Middle Aged, Molecular Sequence Data, Peroxidase, Vasculitis
Circulating antibodies to myeloperoxidase (MPO) are associated primarily with pauci-immune glomerulonephritis and systemic vasculitis. Anti-MPO antibodies belong to a group of autoantibodies, anti-neutrophil cytoplasmic antibodies, that may play a pathogenic role in vasculitis. We have generated a human monoclonal anti-MPO antibody (E3-MPO) using peripheral blood lymphocytes from a patient with microscopic polyarteritis. Variable region gene analysis of E3-MPO showed that the VH region had 90% homology with the germ line gene VH4-21. E3-MPO was also shown to carry the 9G4 idiotope, which so far has been associated only with human antibodies that utilize the VH4-21 gene. The 9G4 idiotope was also expressed on anti-MPO antibodies in sera from the donor patient and from 4/7 additional patients with active, untreated vasculitis. The nucleotide sequences of both the variable heavy and light chains of E3-MPO showed evidence of an antigen-driven response.
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