UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at http://www.ucl.ac.uk/finance/research/post_award/post_award_contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Modeling Alzheimer's disease progression using deep recurrent neural networks
  • Publication Type:
    Conference
  • Authors:
    Nguyen M, Sun N, Alexander DC, Feng J, Thomas Yeo BT
  • Publication date:
    02/08/2018
  • Published proceedings:
    2018 International Workshop on Pattern Recognition in Neuroimaging, PRNI 2018
  • ISBN-13:
    9781538668597
  • Status:
    Published
Abstract
© 2018 IEEE. Multi-step prediction, predicting values multiple steps ahead, is a difficult problem because of the accumulation of error after successive predictions. Recurrent neural networks (RNN) have been applied successfully to multi-step prediction problems such as language modeling where training data are abundant and regular. However, applying RNN to problems in healthcare is still challenging as RNN requires large, feature complete training data in which intervals between time points are fixed which are not reflective of healthcare data. To overcome these problems, we propose strategies to train RNN using missing data which involve using the RNN to fill in the incomplete or missing time points online. The strategies enables the efficient use of training data as well as the adoption of RNN in problems where the variables in a multivariate time series are recorded at irregular intervals or at different frequencies, where there are a lot of missing data. We train RNN using the Alzheimer's Disease Neuroimaging Initiative (ADNI) database to model the monthly progression of Alzheimer's disease for seven years into the future which is a multi-step prediction problem. We show that RNN outperforms baseline models.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Dept of Computer Science
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by