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Publication Detail
Spatiotemporal intracellular dynamics of neurotrophin and its receptors. Implications for neurotrophin signaling and neuronal function.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Bronfman FC, Lazo OM, Flores C, Escudero CA
  • Publication date:
  • Pagination:
    33, 65
  • Journal:
    Handb Exp Pharmacol
  • Volume:
  • Status:
  • Country:
  • Print ISSN:
  • Language:
  • Keywords:
    Amino Acid Sequence, Animals, Axonal Transport, Humans, Molecular Sequence Data, Nerve Growth Factors, Neurons, Protein Transport, Receptors, Nerve Growth Factor, Signal Transduction
Neurons possess a polarized morphology specialized to contribute to neuronal networks, and this morphology imposes an important challenge for neuronal signaling and communication. The physiology of the network is regulated by neurotrophic factors that are secreted in an activity-dependent manner modulating neuronal connectivity. Neurotrophins are a well-known family of neurotrophic factors that, together with their cognate receptors, the Trks and the p75 neurotrophin receptor, regulate neuronal plasticity and survival and determine the neuronal phenotype in healthy and regenerating neurons. Is it now becoming clear that neurotrophin signaling and vesicular transport are coordinated to modify neuronal function because disturbances of vesicular transport mechanisms lead to disturbed neurotrophin signaling and to diseases of the nervous system. This chapter summarizes our current understanding of how the regulated secretion of neurotrophin, the distribution of neurotrophin receptors in different locations of neurons, and the intracellular transport of neurotrophin-induced signaling in distal processes are achieved to allow coordinated neurotrophin signaling in the cell body and axons.
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