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Publication Detail
Effect of medium-term injection of MDMA on the anxiety of male rat with plus maze test
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Jahanshahi M, Nikmahzar EG, Khosravi M, Hosseini FS
  • Publication date:
    01/01/2012
  • Pagination:
    84, 90
  • Journal:
    Journal of Babol University of Medical Sciences
  • Volume:
    14
  • Issue:
    6
  • Status:
    Published
  • Print ISSN:
    1561-4107
Abstract
BACKGROUND AND OBJECTIVE: Acute administration of Methylenedioxymethamphetamine (MDMA) is produced dose-dependent effects on anxiety-related behaviors. High doses of MDMA have anxiolytic effects and low doses of MDMA increases anxiety-like behavior in the elevated plus maze test. The aim of this study was to evaluate the sub-chronic (7 days) effects of low doses of MDMA on anxiety in the male rat. METHODS: In the present experimental study, 28 male Wistar rats were used with approximate weight 20 ± 200 g. Animals were randomly divided into 4 groups, 7 rats were used in each group and experimental groups for a week received different doses of MDMA (1.25, 2.5, 5 mg/kg) and sham group (1 ml/kg), received saline peritoneally. Anxiety one day before injection and 30 minutes after the last injection was performed by the elevated plus maze. FINDINGS: Injection of MDMA significantly increased open arm time percentage that the highest observed in the experimental group received a dose of 5 mg/kg with mean 29.77±33.337. With increasing dose of MDMA increased open arm entry percentage that the difference between experimental group received a dose of 2.5 mg/kg and saline group was statistically significant (p<0.05). MDMA decreased pure index of locomotor activity. MDMA decreased open arm latency that the experimental group received a dose of 2.5 mg/kg less delay in entering the open arm compared to the other experimental groups, averaging 70.83±114.188 showed. CONCLUSION: Low doses of MDMA in sub-chronic (7 day) period can reduce some indices of anxiety in the rats.
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