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Publication Detail
Motor cortical excitability during voluntary inhibition of involuntary tic movements.
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Ganos C, Rocchi L, Latorre A, Hockey L, Palmer C, Joyce EM, Bhatia KP, Haggard P, Rothwell J
  • Publication date:
  • Journal:
    Mov Disord
  • Status:
    Published online
  • Country:
    United States
  • Language:
  • Keywords:
    motor cortical excitability, tic disorders, transcranial magnetic stimulation, voluntary motor control, voluntary tic inhibition
BACKGROUND: Tics can be voluntarily inhibited. However, the neurophysiology of voluntary tic inhibition remains underexplored. The objective of this study was to explore state-dependent effects of voluntary tic inhibition on M1 excitability. METHODS: Neurophysiological assessments (single motor-evoked potentials, corticospinal recruitment curves, short-interval intracortical inhibition, H-reflex) were performed in 14 adults with Tourette syndrome during voluntary tic inhibition and free ticcing. Regressions between behavioral performance and neurophysiological measures were also performed. RESULTS: Voluntary tic inhibition reduced corticospinal excitability: the greater the ability to inhibit tics, the greater was the reduction in excitability. Voluntary tic inhibition was not associated with changes in the excitability of short-interval intracortical inhibition or the H-reflex. CONCLUSIONS: Voluntary inhibition of tics reduces the excitability of corticospinal output. The pattern of neurophysiological findings is consistent with a withdrawal of excitation, but not with modulation of the inhibitory interneuronal mechanisms involved in short-interval intracortical inhibition. © 2018 International Parkinson and Movement Disorder Society.
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Clinical and Movement Neurosciences
Institute of Cognitive Neuroscience
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Clinical and Movement Neurosciences
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