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Publication Detail
A signature pattern of cortical atrophy in dementia with Lewy bodies: A study on 333 patients from the European DLB consortium.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Oppedal K, Ferreira D, Cavallin L, Lemstra AW, Ten Kate M, Padovani A, Rektorova I, Bonanni L, Wahlund L-O, Engedal K, Nobili F, Kramberger M, Taylor J-P, Hort J, Sn├Ždal J, Blanc F, Walker Z, Antonini A, Westman E, Aarsland D, Alzheimer's Disease Neuroimaging Initiative
  • Publisher:
    Elsevier Masson
  • Publication date:
    01/03/2019
  • Journal:
    Alzheimer's and Dementia
  • Status:
    Published online
  • Country:
    United States
  • Print ISSN:
    1552-5260
  • PII:
    S1552-5260(18)33564-7
  • Language:
    eng
  • Keywords:
    Alzheimer's disease, Dementia, Dementia with Lewy bodies, Differential diagnosis, Hippocampal spearing atrophy pattern, Limbic-predominant atrophy pattern, Magnetic resonance imaging, Medial temporal atrophy, Minimal-atrophy pattern, Neuroimaging, Posterior atrophy frontal atrophy, Typical Alzheimer's disease atrophy pattern
Abstract
INTRODUCTION: We explored regional brain atrophy patterns and their clinical correlates in dementia with Lewy bodies (DLB). METHODS: In this multicentre study, we included a total of 333 patients with DLB, 352 patients with Alzheimer's disease (AD), and 233 normal controls and used medial temporal lobe atrophy, posterior atrophy, and frontal atrophy (GCA-F) visual rating scales. Patients were classified according to four atrophy patterns. RESULTS: Patients with DLB had higher scores on all the three atrophy scales than healthy controls but had less medial temporal lobe atrophy than those with AD (all P-values < .001). A signature hippocampal-sparing pattern of regional atrophy was observed in DLB. The magnetic resonance imaging measures showed 65% ability to discriminate between DLB and AD and marginally contributed to the discrimination over and above the core clinical features. DISCUSSION: The most common pattern of atrophy of DLB was hippocampal-sparing. Future studies should explore whether comorbid AD pathology underlies the atrophy patterns seen in DLB.
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