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Publication Detail
Bridging trees for posterior inference on ancestral recombination graphs
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Heine K, Beskos A, Jasra A, Balding D, De Iorio M
  • Publisher:
    The Royal Society
  • Publication date:
    01/12/2018
  • Journal:
    Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences
  • Volume:
    474
  • Issue:
    2220
  • Article number:
    20180568
  • Status:
    Published
  • Print ISSN:
    1364-5021
  • Language:
    English
  • Keywords:
    tree scanning, Markov chain Monte Carlo, coalescent, ancestral recombination graph, Bayesian inference
Abstract
We present a new Markov chain Monte Carlo algorithm, implemented in the software Arbores, for inferring the history of a sample of DNA sequences. Our principal innovation is a bridging procedure, previously applied only for simple stochastic processes, in which the local computations within a bridge can proceed independently of the rest of the DNA sequence, facilitating large-scale parallelization.
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