Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at http://www.ucl.ac.uk/finance/research/post_award/post_award_contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Quantifying small changes in brain ventricular volume using non-rigid registration
  • Publication Type:
  • Authors:
    Holden M, Schnabel JA, Hill DLG
  • Publication date:
  • Pagination:
    49, 56
  • Published proceedings:
    Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
  • Volume:
  • ISBN-10:
  • ISBN-13:
  • Status:
  • Print ISSN:
© Springer-Verlag Berlin Heidelberg 2001. Non-rigid registration can automatically quantify small changes in volume of anatomical structures over time by means of segmentation propagation. Here we use a non-rigid registration algorithm based on optimising normalised mutual information to quantify small changes in brain ventricular volume in MR images of a group of five patients treated with growth hormone replacement therapy and a control group of six volunteers. The lateral ventricles are segmented from each subject image by registering the brainweb image [1] which has this structure delineated. The mean (standard deviation) volume change measurements are 1.09cc (0.73cc) for the patient group and 0.08cc (0.62cc) for the volunteer group, this difference is statistically significant at the 1% level.We validate our volume change measurements by comparing them to previously published results obtained by visual inspection of difference images, and demonstrate high rank correlation coefficient (ρ = 0.7, n=11).
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Dept of Med Phys & Biomedical Eng
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by