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Publication Detail
Deformation based morphometry analysis of serial magnetic resonance images of mouse brains
  • Publication Type:
    Conference
  • Authors:
    Maheswaran S, Barjat H, Bate S, Hartkens T, Hill DLG, James MF, Tilling L, Upton N, Hajnal J, Rueckert D
  • Publication date:
    01/01/2006
  • Pagination:
    58, 65
  • Published proceedings:
    Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
  • Volume:
    4057 LNCS
  • ISBN-10:
    3540356487
  • ISBN-13:
    9783540356486
  • Status:
    Published
  • Print ISSN:
    0302-9743
Abstract
Deformation based morphometry is used to detect differences in in-vivo Magnetic Resonance Image (MRI) of the mouse brain obtained from two transgenic strains: TASTPM mice that over-express proteins associated with Alzheimer's disease, and wild-type mice. MRI was carried out at four time points. We compare two different methods to detect group differences in the longitudinal and cross-sectional data. Both methods are based on non-rigid registration of the images to a mouse brain atlas. The whole brain volume measurements on 27 TASTPM and wild-type animals are reproducible to within 0.4% of whole brain volume. The agreement between different methods for measuring volumes in a serial study is shown. The ability to quantify changes in growth between strains in whole brain, hippocampus and cerebral cortex is demonstrated. © Springer-Verlag Berlin Heidelberg 2006.
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