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Publication Detail
Analysis of serial magnetic resonance images of mouse brains using image registration
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Maheswaran S, Barjat H, Bate ST, Aljabar P, Hill DLG, Tilling L, Upton N, James MF, Hajnal JV, Rueckert D
  • Publication date:
  • Pagination:
    692, 700
  • Journal:
  • Volume:
  • Issue:
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The aim of this paper is to investigate techniques that can identify and quantify cross-sectional differences and longitudinal changes in vivo from magnetic resonance images of murine models of brain disease. Two different approaches have been compared. The first approach is a segmentation-based approach: Each subject at each time point is automatically segmented into a number of anatomical structures using atlas-based segmentation. This allows cross-sectional and longitudinal analyses of group differences on a structure-by-structure basis. The second approach is a deformation-based approach: Longitudinal changes are quantified by the registration of each subject's follow-up images to that subject's baseline image. In addition the baseline images can be registered to an atlas allowing voxel-wise analysis of cross-sectional differences between groups. Both approaches have been tested on two groups of mice: A transgenic model of Alzheimer's disease and a wild-type background strain, using serial imaging performed over the age range from 6-14 months. We show that both approaches are able to identify longitudinal and cross-sectional differences. However, atlas-based segmentation suffers from the inability to detect differences across populations and across time in regions which are much smaller than the anatomical regions. In contrast to this, the deformation-based approach can detect statistically significant differences in highly localized areas. © 2008 Elsevier Inc. All rights reserved.
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