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Publication Detail
Early onset cerebral amyloid angiopathy following childhood exposure to cadaveric dura
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Publication Type:Journal article
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Publication Sub Type:Article
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Authors:Banerjee G, Adams ME, Jaunmuktane Z, Lammie GA, Turner B, Wani M, Sawhney IMS, Houlden H, Mead S, Brandner S, Werring DJ
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Publisher:Wiley-Blackwell
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Publication date:01/02/2019
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Journal:Annals of Neurology
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Status:Published online
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Country:United States
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Print ISSN:0364-5134
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Language:eng
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Keywords:Amyloid-beta, Cerebral amyloid angiopathy, Prion
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Author URL:
Abstract
Amyloid-β transmission has been described in patients both with and without iatrogenic Creutzfeldt-Jakob disease; however, there is little information regarding the impact of this acquired amyloid-β pathology during life. Here, for the first time, we describe in detail the clinical and neuroimaging findings in three patients with early-onset symptomatic amyloid-β cerebral amyloid angiopathy following childhood exposure to cadaveric dura (by neurosurgical grafting in two patients, and tumour embolization in a third). Our observations provide further in vivo evidence that cerebral amyloid angiopathy might be caused by transmission of amyloid-β seeds (prions) present in cadaveric dura, and has diagnostic relevance for younger patients presenting with suspected cerebral amyloid angiopathy. This article is protected by copyright. All rights reserved.
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