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Publication Detail
Aminopolyols from carbohydrates: the amination of sugars and sugar‚Äźderived tetrahydrofurans with transaminases
Carbohydrates are the major component of biomass and have unique potential as a sustainable source of building blocks for chemicals, materials and biofuels due to their low cost, ready availability and stereochemical diversity. With a view to upgrading carbohydrates to access valuable nitrogen containing sugar-like compounds such as aminopolyols, biocatalytic aminations using transaminase enzymes (TAms) have been investigated as a sustainable alternative to traditional synthetic strategies. Here we demonstrate the reaction of TAms with sugar-derived tetrahydrofuran (THF) aldehydes, obtained from the regioselective dehydration of biomass-derived sugars, to provide access to cyclic aminodiols in high yields. In a preliminary study we have also established the direct transamination of sugars to give acyclic aminopolyols. Notably, the reaction of the ketose D-fructose proceeds with complete stereoselectivity to yield valuable aminosugars in high purity.
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