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Publication Detail
Comparison of label-free quantification methods for the determination of protein complexes subunits stoichiometry
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Fabre B, Lambour T, Bouyssié D, Menneteau T, Monsarrat B, Burlet-Schiltz O, Bousquet-Dubouch MP
  • Publication date:
    25/06/2014
  • Pagination:
    82, 86
  • Journal:
    EuPA Open Proteomics
  • Volume:
    4
  • Status:
    Published
  • Print ISSN:
    2212-9685
Abstract
© 2014 The Authors. Protein complexes are the main molecular machines that support all major cellular pathways and their in-depth characterization are essential to understand their functions. Determining the stoichiometry of the different subunits of a protein complex still remains challenging. Recently, many label-free quantitative proteomic approaches have been developed to study the composition of protein complexes. It is therefore of great interest to evaluate these different methods in a stoichiometry oriented objective. Here we compare the ability of four absolute quantitative label-free methods currently used in proteomic studies to determine the stoichiometry of a well-characterized protein complex, the 26S proteasome.
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