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Publication Detail
Beta-amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Bourgeat P, Chételat G, Villemagne VL, Fripp J, Raniga , P , Pike , K , Acosta , O , Szoeke , C , Ourselin , S , Ames , D , Ellis , KA , Martins , RN , Masters , CL , Rowe , CC S, O
  • Publication date:
    2010
  • Pagination:
    121, 127
  • Journal:
    Neurology
  • Volume:
    74
  • Issue:
    2
  • Status:
    Published
  • Print ISSN:
    0028-3878
Abstract
Objective: To investigate whether global and regional -amyloid (A ) burden as measured with 11C Pittsburgh compound B (PIB) PET is associated with hippocampal atrophy characterized using MRI in healthy controls and patients with amnestic mild cognitive impairment (aMCI) or Alzheimer disease (AD). Methods: Ninety-two elderly healthy controls, 32 subjects with aMCI, and 35 patients with AD were imaged using 11C-PIB PET and MRI. Hippocampal volume was measured and PIB standardized uptake value ratio was extracted after partial volume correction within 41 regions of interest. Global, regional, and voxel-based correlations between PIB and hippocampal volume were computed for each group. Results: In healthy control participants with elevated neocortex PIB retention, significant correlation was found between PIB retention in the inferior temporal region and hippocampal volume using both region-based and voxel-based approaches. No correlation was found in any other group. Conclusions: The strong correlation between hippocampal atrophy and -amyloid (A ) burden in the Pittsburgh compound B–positive healthy control group suggests that A deposition in the inferior temporal neocortex is related to hippocampal synaptic and neuronal degeneration.
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