Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
The contribution of multiparametric pelvic & whole body MR to interpretation of 18F-fluoromethylcholine or 68Ga-HBED-CC PSMA-11 PET/CT in patients with biochemical failure following radical prostatectomy.
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Metser U, Chua SS-C, Ho B, Punwani S, Johnston E, Pouliot F, Tau N, Hawsawy A, Anconina R, Bauman G, Hicks RJ, Weickhardt A, Davis ID, Pond G, Scott A, Tunariu N, Sidhu H, Emmett LM
  • Publication date:
  • Journal:
    Journal of Nuclear Medicine
  • Status:
    Published online
  • Country:
    United States
  • PII:
  • Language:
  • Keywords:
    Biochemical recurrence, FCH, MRI, Oncology: GU, PET, PET/CT, PSMA PET, Radiopharmaceuticals, multiparameteric MR, whole body MR
Purpose: To assess whether the addition of data from multiparametric pelvic (mpMR) and whole body MR (wbMR) to the interpretation of 18F-fluoromethylcholine (FCH) or 68Ga-HBED-CC PSMA-11 (PSMA) PET/CT (=PET) improves the detection of local tumor recurrence, or nodal and distant metastases in patients following radical prostatectomy with biochemical failure. Methods: The current analysis was performed as part of a prospective, multicenter trial on FCH / PSMA PET, mpMR and wbMR. Eligible men had elevated PSA (>0.2 ng/ml) and high-risk features (Gleason score >7, PSA doubling time < 10 months, or PSA>1.0 ng/ml) with negative/ equivocal conventional imaging. PET was interpreted with mp&wbMR in consensus by 2 radiologists and compared to prospective interpretation of PET or MR alone. Performance measures of each modality (PET, MR & PET/mp-wbMR) were compared for each radiotracer, for each individual patient (for FCH, or PSMA for patients who had PSMA PET), and to a composite reference standard. Results: There were 86 patients with PET (FCH [n = 76] and/or PSMA [n = 26]) who had mp&wbMR. Local tumor recurrence was detected in 20/76 (26.3%) on FCH PET/mpMR vs 11/76 (14.5%) on FCH PET (P = 0.039) and 11/26 (42.3%) on PSMA PET/mpMR vs 6/26 (23.1%) on PSMA PET (P = 0.074). Per patient, PET/mpMR was more often positive for local tumor recurrence than PET (P = 0.039) or mpMR (P = 0.019). There were 20/86 (23.3%) patients with regional nodal metastases on both PET/wbMR, and PET (P = 1.0) but only 12/86 (14%) on wbMR (P = 0.061). Similarly, there were more nonregional metastases detected on PET/wbMR than on PET (P = 0.683) and wbMR (P = 0.074), but these differences did not reach significance. Compared to the composite reference standard for the detection of disease beyond the prostatic fossa PET/wbMR, PET and wbMR had sensitivity of 50%, 50%, 8.3%, respectively & specificity of 97.1%, 97.1%, 94.1%, respectively. Conclusion: Interpretation of PET with mpMR resulted in a higher detection rate for local tumor recurrence in the prostate bed in men with biochemical failure following radical prostatectomy. However, the addition of wbMR to FCH/PSMA PET did not improve detection of regional or distant metastases.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Department of Imaging
Div of Medicine
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by