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Publication Detail
The fast activating potassium current, I(K,f), in guinea-pig inner hair cells is regulated by protein kinase A.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Jagger DJ, Ashmore JF
  • Publication date:
  • Pagination:
    145, 148
  • Journal:
    Neurosci Lett
  • Volume:
  • Issue:
  • Status:
  • Country:
  • Print ISSN:
  • PII:
  • Language:
  • Keywords:
    4-Aminopyridine, 8-Bromo Cyclic Adenosine Monophosphate, Animals, Cyclic AMP-Dependent Protein Kinases, Egtazic Acid, Enzyme Inhibitors, Guinea Pigs, Hair Cells, Auditory, Inner, In Vitro Techniques, Isoquinolines, Kinetics, Membrane Potentials, Patch-Clamp Techniques, Potassium Channels, Sulfonamides
The mammalian inner hair cell (IHC) responds to displacements produced in the cochlea by sound by releasing neurotransmitter from its basal pole. A basolateral fast activating potassium current, called I(K,f), allows IHCs to act as sensory cells at high frequencies by shortening the membrane time constant. This current is co-expressed with a slower activating current, I(K,s). We have studied the intracellular regulation of IHC currents using the whole-cell patch clamp technique in conjunction with agents that influence the function of protein kinase A (PKA). Bath applied 8-Bromo-cAMP, an activator of PKA, increased the amplitude of outwardly rectifying currents and shortened the exponential time constant of activation. Following blockade of I(K,s) by intracellular 4-AP, I(K,f) could be reduced in amplitude by H-89, an inhibitor of PKA. Our results suggest that PKA regulates I(K,f) and so shapes the frequency response of IHCs.
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