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Publication Detail
CHARACTERISATION OF ASTROCYTES IN FRONTOTEMPORAL LOBAR DEMENTIAS USING POST-MORTEM TISSUE
  • Publication Type:
    Conference presentation
  • Publication Sub Type:
    Presentation
  • Authors:
    Foti S, Toomey C, Lashley T
  • Name of Conference:
    Alzheimer's Disease and Parkinson's Disease UK
  • Conference place:
    Lisbon, Portugal
  • Conference start date:
    27/03/2019
  • Conference finish date:
    31/03/2019
  • Addresses:
    Queen Square Brain Bank for Neurological disorders
    University College London
    Department of Neurodegenerative diseases
    1 Wakefield Street
    London
    WC1N 1PJ
    United Kingdom
Abstract
Objectives: Frontotemporal lobar degenerations (FTLDs) are collectively the second most common form of young onset dementia. Around 50% of FTLDs contain the TAR-DNA binding protein-43 (TDP-43) protein in the pathological inclusions. FTLD-TDP can be divided into four pathological subtypes, Type A, B, C and D based on type and location of the inclusions. Astrocytes have been shown to be involved in Alzheimer’s disease (AD) pathogenesis, however little is known about their potential role in FTLD-TDP subtypes. There is evidence of astrocytic pathology in these subtypes however the phenotypic traits of astrocytes is still unknown and may play a role in FTLD-TPD subtype-specific pathology. Methods: Eight µm sections from the frontal cortex from neurologically normal controls (n=5), AD (n=5), sporadic FTD-TDP type A (n=5), B (n=4), C (n=5) were immunohistochemically stained with a range of astrocytic markers, including GFAP, EAAT1, EAAT2 and S100β. Sections were qualitatively analysed and compared across the cohorts. Results: Using a range of astrocytic markers targeting, intermediate filament proteins, amino acid transporters and calcium binding proteins reflects an array of astrocytic morphologies which differ between white and grey matter within frontal cortices as well as between disease groups. Conclusions: It is clear that using the ‘gold standard’ GFAP marker may be masking the role of different phenotypic astrocytes. These markers have elucidated a range of astrocyte morphologies as well as protein expression using immunohistochemical techniques.
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