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Publication Detail
Polarized Two-Photon Absorption and Heterogeneous Fluorescence Dynamics in NAD(P)H
Abstract
Two-photon absorption (2PA) finds widespread application in biological systems, which frequently exhibit heterogeneous fluorescence decay dynamics corresponding to multiple species or environments. By combining polarised 2PA with time-resolved fluorescence intensity and anisotropy decay measurements, we show how the two-photon transition tensors for the components of a heterogeneous population can be separately determined, allowing structural differences between the two fluorescent states of the redox cofactor NAD(P)H to be identified. The results support the view that the two states correspond to alternate configurations of the nicotinamide ring, rather than folded and extended conformations of the entire molecule.
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Dept of Physics & Astronomy
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Dept of Physics & Astronomy
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Cell & Developmental Biology
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