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Publication Detail
The role of hsp90 in sle
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Latchman DS, Isenberg DA
  • Publication date:
    01/01/1994
  • Pagination:
    211, 218
  • Journal:
    Autoimmunity
  • Volume:
    19
  • Issue:
    3
  • Status:
    Published
  • Print ISSN:
    0891-6934
Abstract
The heat shock proteins are a group of evolutionarily conserved proteins with important physiological functions, whose synthesis is enhanced by elevated temperature or other stresses. A role for one or more of these proteins in human autoimmune disease has been extensively discussed. This review considers the evidence of a role for hsp90 in systemic lupus erythematosus (SLE) where over-expression of this protein, its surface localization and auto-antibodies to it have been observed in both human patients and in the MRL/1pr mouse model of SLE. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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