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Publication Detail
Elevation of the 90 kDa heat-shock protein in specific subsets of systemic lupus erythematosus
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Dhillon VB, Mc Callum S, Latchman DS, Isenberg DA
  • Publication date:
    01/01/1994
  • Pagination:
    215, 222
  • Journal:
    QJM
  • Volume:
    87
  • Issue:
    4
  • Status:
    Published
  • Print ISSN:
    1460-2725
Abstract
We have previously shown that the 90 kDa heat- shock protein (hsp9o) is notably elevated in lupus patients with active neuro-psychiatric (NP) and/or cardio-respiratory (CR) disease. This elevation is dependent upon enhanced transcription of the hsp90. Serial studies have shown that changes inhsp9o levels have a high level of sensitivity for changes in activity of NP, CR, haematological and renal SLE. We now present evidence that overexpression of hsp9o in lupus patients is associated with the presence of the anti-phospholipid syndrome, and with the absence of the HLA allo-/haplotypes most commonly found in this particular cohort of patients. We conclude that the upregulation of hsp90 expression in SLE has a genetic basis, and that this may be directly involved in pathogenesis in subsets of patients with this disease. © 1994 Oxford University Press.
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