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Publication Detail
Detection of autoantibodies to the 90 kDa head shock protein in systemic lupus erythematosus and other autoimmune diseases
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Conroy SE, Faulds GB, Williams W, Latchman DS, Isenberg DA
  • Publication date:
    01/10/1994
  • Pagination:
    923, 926
  • Journal:
    Rheumatology
  • Volume:
    33
  • Issue:
    10
  • Status:
    Published
  • Print ISSN:
    1462-0324
Abstract
Expression of the highly conserved 90 kDa heat shock protein (Hsp90) is elevated in the peripheral blood mononuclear cells of approximately 25% of patients with SLE. Conflicting data have been published about the frequency of antibodies to Hsp90 with the previous methodology using a complex Western blot system. We now describe an ELISA to measure autoantibodies to Hsp90 and Hsp70 in SLE patients, healthy controls and patients with a variety of autoimmune rheumatic diseases, IgG and IgM antibodies were elevated in 26 and 35% of SLE patients, respectively. These results show autoantibodies to Hsp90 (but not Hsp70) are elevated in a significant proportion of patients with SLE (P<0.025) compared to healthy controls; and that those with raised antibody levels were more likely to have renal disease and a low C3 level (P<0.02). © 1994 British Society for Rheumatology.
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