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Publication Detail
The role of gut hormones in the pathogenesis and management of obesity
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Review
  • Authors:
    Makaronidis JM, Batterham RL
  • Publication date:
    12/2019
  • Pagination:
    1, 11
  • Journal:
    Current Opinion in Physiology
  • Volume:
    12
  • Status:
    Accepted
  • Print ISSN:
    2468-8681
Abstract
© 2019 The growing obesity epidemic is driving the need for the development of novel, effective therapeutic strategies for obesity and its complications. Increasing our understanding of the processes controlling body weight is therefore imperative. Gut hormones have emerged as essential regulators of energy homeostasis. Dysregulation of gut hormone physiology is increasingly implicated in obesity pathogenesis and the compensatory biological responses driving weight regain following energy restriction. Furthermore, gut hormones are among key mediators of the weight loss following Roux-en-Y gastric bypass and sleeve gastrectomy, the bariatric procedures which remain the most effective treatment for severe obesity. Therapeutic strategies targeting gut hormones and their receptors are driving a new pharmacotherapy era and constitute the most promising approach to addressing the obesity epidemic.
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