UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart
  • Publication Type:
    Working discussion paper
  • Authors:
    Lowe V, Wisniewski L, Sayers J, Frankel P, Mercader-Huber N, Zachary I, Pellet-Many C
  • Publication date:
    13/11/2018
  • Status:
    Published
Abstract
Abstract Unlike adult mammals, zebrafish are able to naturally regenerate their heart. A key mechanism in zebrafish heart regeneration is the activation of the epicardium, leading to the establishment of a supporting scaffold for newly formed cardiomyocytes, angiogenesis and cytokine secretion. Neuropilins (NRPs) are cell surface co-receptors mediating functional signaling of kinase receptors for cytokines known to play critical roles in zebrafish heart regeneration, including Platelet-Derived growth factor (PDGF), Vascular Endothelial growth factor (VEGF), and Fibroblast growth factor (FGF). Herein, we investigated the role of neuropilins in the response of the zebrafish heart to injury and its subsequent regeneration. All four zebrafish neuropilin isoforms, nrp 1a , 1b , 2a , and 2b , were upregulated following cardiac cryoinjury and were strongly expressed by the activated epicardium. A nrp1a mutant, coding for a truncated, non-functional protein, showed a significant delay in heart regeneration in comparison to Wild-Type fish and displayed persistent collagen deposition. The regenerating hearts of nrp1a mutants were less vascularized and epicardial-derived cell migration and re-expression of the developmental gene Wilms’ tumor 1 was severely impaired in nrp1a mutants. Moreover, cryoinjury-induced activation and migration of epicardial cells in heart explants was strongly reduced in nrp1a mutant zebrafish. These results identify a key role for Nrp1 in zebrafish heart regeneration, mediated through epicardial activation, migration and revascularization.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Metabolism & Experi Therapeutics
Author
Metabolism & Experi Therapeutics
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by