UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at http://www.ucl.ac.uk/finance/research/post_award/post_award_contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
RNA-binding protein Csx1 mediates global control of gene expression in response to oxidative stress.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Rodríguez-Gabriel MA, Burns G, McDonald WH, Martín V, Yates JR, Bähler J, Russell P
  • Publication date:
    01/12/2003
  • Pagination:
    6256, 6266
  • Journal:
    EMBO J
  • Volume:
    22
  • Issue:
    23
  • Status:
    Published
  • Country:
    England
  • Print ISSN:
    0261-4189
  • Language:
    eng
  • Keywords:
    Fungal Proteins, Gene Expression Regulation, Homeobox Protein Nkx-2.5, Homeodomain Proteins, Mutagenesis, Insertional, Oligonucleotide Array Sequence Analysis, Oxidative Stress, Phosphorylation, RNA, Messenger, RNA-Binding Proteins, Recombinant Proteins, Schizosaccharomyces, Transcription Factors
Abstract
Fission yeast Spc1 (Sty1), a stress-activated mitogen-activated protein kinase (MAPK) homologous to human p38, orchestrates global changes in gene expression in response to diverse forms of cytotoxic stress. This control is partly mediated through Atf1, a transcription factor homologous to human ATF2. How Spc1 controls Atf1, and how the cells tailor gene expression patterns to different forms of stress, are unknown. Here we describe Csx1, a novel protein crucial for survival of oxidative but not osmotic stress. Csx1 associates with and stabilizes atf1+ mRNA in response to oxidative stress. Csx1 controls expression of the majority of the genes induced by oxidative stress, including most of the genes regulated by Spc1 and Atf1. These studies reveal a novel mechanism controlling MAPK-regulated transcription factors and suggest how gene expression patterns can be customized to specific forms of stress. Csx1-like proteins in humans may perform similar tasks.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Genetics, Evolution & Environment
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by