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Publication Detail
Actin nucleation: spire - actin nucleator in a class of its own.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Baum B, Kunda P
  • Publication date:
  • Pagination:
    R305, R308
  • Journal:
    Curr Biol
  • Volume:
  • Issue:
  • Status:
  • Country:
  • Print ISSN:
  • PII:
  • Language:
  • Keywords:
    Actins, Adenosine Triphosphate, Cytoskeletal Proteins, Drosophila Proteins, Microfilament Proteins, Models, Biological, Multiprotein Complexes, Protein Binding
The rate limiting step for actin filament polymerisation is nucleation, and two types of nucleator have been described: the Arp2/3 complex and the formins. A recent study has now identified in Spire a third class of actin nucleator. The four short WH2 repeats within Spire bind four consecutive actin monomers to form a novel single strand nucleus for 'barbed end' actin filament elongation.
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