UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Lack of evidence for interhemispheric inhibition in the lower face primary motor cortex.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Ginatempo F, Manzo N, Rothwell JC, Deriu F
  • Publisher:
    Elsevier
  • Publication date:
    01/10/2019
  • Pagination:
    1917, 1925
  • Journal:
    Clinical Neurophysiology
  • Volume:
    130
  • Issue:
    10
  • Status:
    Published
  • Country:
    Netherlands
  • Print ISSN:
    1388-2457
  • PII:
    S1388-2457(19)31182-4
  • Language:
    eng
  • Keywords:
    Brainstem, Corpus callosum, Face primary motor cortex, Facial muscles, IHI, Interhemispheric inhibition
Abstract
OBJECTIVE: To investigate interhemispheric inhibition (IHI) between the facial primary motor cortices (fM1s). METHODS: IHI was investigated in 10 healthy subjects using paired-pulse TMS in the depressor anguli oris (DAO), upper trapezius (UT) and first dorsal interosseous (FDI) muscles. Conditioning stimuli (CS) of 90-130% resting motor threshold (RMT) preceded test motor evoked potentials (MEPs) by 7 interstimulus intervals (ISIs) ranging 4-12 ms. In the DAO, we also examined IHI at 1-2 ms ISIs. RESULTS: IHI was detected in the UT (CS 130% RMT; ISI 8 ms; p = 0.02) and FDI (CS 120% and 130% RMT, at 8-10 ms ISIs; p = 0.004), but not in DAO at any ISI, instead, there was facilitation at 1-4 ms ISIs and 110-130% RMT CS. In the DAO, conditioned responses at 1-4 ms ISIs were significantly larger than both test MEPs and the response induced by the CS alone. CONCLUSION: In the DAO there was no evidence of IHI even though this was clear in hand and axial muscles. Control experiments excluded a transcallosal origin of the facilitation observed at the shortest intervals. SIGNIFICANCE: Data suggest that integrated bilateral control of facial muscles occurs mainly at the level of brainstem circuits engaged by corticobulbar output from fM1.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Clinical and Movement Neurosciences
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by