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Publication Detail
Post-transcriptional control of gene expression: a genome-wide perspective.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Mata J, Marguerat S, Bähler J
  • Publication date:
    09/2005
  • Pagination:
    506, 514
  • Journal:
    Trends Biochem Sci
  • Volume:
    30
  • Issue:
    9
  • Status:
    Published
  • Country:
    England
  • Print ISSN:
    0968-0004
  • PII:
    S0968-0004(05)00212-4
  • Language:
    eng
  • Keywords:
    Gene Expression Profiling, Gene Expression Regulation, Humans, Oligonucleotide Array Sequence Analysis, Protein Processing, Post-Translational, RNA Interference, RNA, Messenger, RNA-Binding Proteins
Abstract
Gene expression is regulated at multiple levels, and cells need to integrate and coordinate different layers of control to implement the information in the genome. Post-transcriptional levels of regulation such as transcript turnover and translational control are an integral part of gene expression and might rival the sophistication and importance of transcriptional control. Microarray-based methods are increasingly used to study not only transcription but also global patterns of transcript decay and translation rates in addition to comprehensively identify targets of RNA-binding proteins. Such large-scale analyses have recently provided supplementary and unique insights into gene expression programs. Integration of several different datasets will ultimately lead to a system-wide understanding of the varied and complex mechanisms for gene expression control.
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