UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Differential expression of CD180 and IgM by B-cell chronic lymphocytic leukaemia cells using mutated and unmutated immunoglobulin VH genes
  • Publication Type:
    Journal article
  • Authors:
    Porakishvili N, Kulikova N, Jewell AP, Youinou PY, Yong K, Nathwani A, Heelan B, Duke V, Hamblin TJ, Wallace P, Ely P, Clark EA, Lydyard PM
  • Publisher:
    BLACKWELL PUBLISHING
  • Publication date:
    11/2005
  • Pagination:
    313, 319
  • Journal:
    BRIT J HAEMATOL
  • Volume:
    131
  • Issue:
    3
  • Print ISSN:
    0007-1048
  • Keywords:
    B-cell chronic lymphocytic leukaemia, CD180, toll-like receptor, IGVH mutation, TOLL-LIKE RECEPTORS, CD38 EXPRESSION, RP105, ACTIVATION, APOPTOSIS, DISEASE, ANTIBODIES, PHENOTYPE, MOLECULE, REVEALS
Abstract
We have studied the surface expression of the Toll-like receptor family member CD180 on cells from 78 patients with B-chronic lymphocytic leukaemia (B-CLL). B-CLL cells had variable levels of CD180 expression, but this was always less than that expressed by normal blood B cells and was stable for 24 months. Significantly higher levels of CD180 were expressed by B-CLL cells with mutated IGVH genes compared with those using unmutated IGVH genes. This was in contrast to the higher levels of expression of surface immunoglobulin M by B-CLL cells using unmutated, rather than mutated IGVH genes. CD180 was functional on B-CLL cells from some of the patients, as shown by the increased expression of CD86 following incubation in vitro with anti-CD180. The differential expression of CD180 amongst B-CLL patients is one more marker that may define more precisely the different biological properties of this heterogeneous disease.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Div of Infection & Immunity
Author
Research Department of Haematology
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by