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Publication Detail
Novel suppressive function of transitional 2 B cells in experimental arthritis.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Evans JG, Chavez-Rueda KA, Eddaoudi A, Meyer-Bahlburg A, Rawlings DJ, Ehrenstein MR, Mauri C
  • Publication date:
    15/06/2007
  • Pagination:
    7868, 7878
  • Journal:
    J Immunol
  • Volume:
    178
  • Issue:
    12
  • Status:
    Published
  • Country:
    United States
  • Print ISSN:
    0022-1767
  • PII:
    178/12/7868
  • Language:
    eng
  • Keywords:
    Adoptive Transfer, Animals, Arthritis, Experimental, B-Lymphocyte Subsets, B-Lymphocytes, Collagen Type II, Immune Tolerance, Immunoglobulin M, Interferon-gamma, Interleukin-10, Lymphocyte Activation, Mice, Phenotype, Receptors, Complement 3d, Receptors, IgE, Th1 Cells
Abstract
The immune system contains natural regulatory cells important in the maintenance of tolerance. Although this suppressive function is usually attributed to CD4 regulatory T cells, recent reports have revealed an immunoregulatory role for IL-10-producing B cells in the context of several autoimmune diseases including collagen-induced arthritis. In the present study, we attribute this suppressive function to a B cell subset expressing high levels of CD21, CD23, and IgM, previously identified as transitional 2-marginal zone precursor (T2-MZP) B cells. T2-MZP B cells are present in the spleens of naive mice and increase during the remission phase of arthritis. Following adoptive transfer to immunized DBA/1 mice, T2-MZP B cells significantly prevented new disease and ameliorated established disease. The suppressive effect on arthritis was paralleled by an inhibition of Ag-specific T cell activation and a reduction in cells exhibiting Th1-type functional responses. We also provide evidence that this regulatory subset mediates its suppression through the secretion of suppressive cytokines and not by cell-to-cell contact. The ability to regulate an established immune response by T2-MZP B cells endows this subset of B cells with a striking and previously unrecognized immunoregulatory potential.
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