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Publication Detail
Possible role of backpropagating action potentials in corticospinal neurons in I-wave periodicity following a TMS pulse
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Ugawa Y, Rothwell JC, Paulus W
  • Publication date:
    28/10/2019
  • Journal:
    Neuroscience Research
  • Status:
    Published online
  • Country:
    Ireland
  • PII:
    S0168-0102(19)30547-4
  • Language:
    eng
  • Keywords:
    Dendric computation Backpropagation activated coupling, I wave, Motor cortex, TMS, dendrite
Abstract
A single pulse of TMS or direct electric stimulation over M1 causes repetitive synchronized firing of corticospinal tract (CST) neurons. Two mechanisms for the repetitive firing have been proposed: a cascade of synaptic inputs to the pyramidal neurons and a single reverberating circuit of interneurons. Here, we propose another possibility in which bursting of CST neurons is produced by dendritic Ca2+-spikes. Backpropagation of the initial action potential (I1-wave) from the soma interacts with synaptic input in the dendrites to initiate a dendritic calcium spike. These Ca2+-spikes produce a burst of somatic action potentials that starts about 1.5 ms after the initial discharge of the neuron, which may produce the later I-waves.
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