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Publication Detail
Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    López-Maury L, Marguerat S, Bähler J
  • Publication date:
  • Pagination:
    583, 593
  • Journal:
    Nat Rev Genet
  • Volume:
  • Issue:
  • Status:
  • Country:
  • PII:
  • Language:
  • Keywords:
    Adaptation, Biological, Animals, Biological Evolution, Circadian Rhythm, Environment, Gene Expression Regulation, Growth and Development, Homeostasis, Humans, Models, Biological, Stress, Physiological, Time Factors, Transcription, Genetic
Organisms are constantly exposed to a wide range of environmental changes, including both short-term changes during their lifetime and longer-term changes across generations. Stress-related gene expression programmes, characterized by distinct transcriptional mechanisms and high levels of noise in their expression patterns, need to be balanced with growth-related gene expression programmes. A range of recent studies give fascinating insight into cellular strategies for keeping gene expression in tune with physiological needs dictated by the environment, promoting adaptation to both short- and long-term environmental changes. Not only do organisms show great resilience to external challenges, but emerging data suggest that they also exploit these challenges to fuel phenotypic variation and evolutionary innovation.
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