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Publication Detail
Fission yeast SWI/SNF and RSC complexes show compositional and functional differences from budding yeast.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Monahan BJ, Villén J, Marguerat S, Bähler J, Gygi SP, Winston F
  • Publication date:
    08/2008
  • Pagination:
    873, 880
  • Journal:
    Nat Struct Mol Biol
  • Volume:
    15
  • Issue:
    8
  • Status:
    Published
  • Country:
    United States
  • PII:
    nsmb.1452
  • Language:
    eng
  • Keywords:
    Actins, Chromatin, Chromosomal Proteins, Non-Histone, DNA-Binding Proteins, Gene Deletion, Gene Expression Regulation, Fungal, Humans, Nuclear Proteins, Phenotype, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Schizosaccharomyces, Schizosaccharomyces pombe Proteins, Species Specificity, Transcription Factors, Transcription, Genetic
Abstract
SWI/SNF chromatin-remodeling complexes have crucial roles in transcription and other chromatin-related processes. The analysis of the two members of this class in Saccharomyces cerevisiae, SWI/SNF and RSC, has heavily contributed to our understanding of these complexes. To understand the in vivo functions of SWI/SNF and RSC in an evolutionarily distant organism, we have characterized these complexes in Schizosaccharomyces pombe. Although core components are conserved between the two yeasts, the compositions of S. pombe SWI/SNF and RSC differ from their S. cerevisiae counterparts and in some ways are more similar to metazoan complexes. Furthermore, several of the conserved proteins, including actin-like proteins, are markedly different between the two yeasts with respect to their requirement for viability. Finally, phenotypic and microarray analyses identified widespread requirements for SWI/SNF and RSC on transcription including strong evidence that SWI/SNF directly represses iron-transport genes.
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