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Publication Detail
Cdc42, Par6, and aPKC regulate Arp2/3-mediated endocytosis to control local adherens junction stability.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Georgiou M, Marinari E, Burden J, Baum B
  • Publication date:
  • Pagination:
    1631, 1638
  • Journal:
    Curr Biol
  • Volume:
  • Issue:
  • Country:
  • Print ISSN:
  • PII:
  • Language:
  • Keywords:
    Actin-Related Protein 2-3 Complex, Actins, Adherens Junctions, Animals, Cadherins, Cytoskeleton, Drosophila, Drosophila Proteins, Dynamins, Endocytosis, Protein Kinase C, Pupa, Wiskott-Aldrich Syndrome Protein, cdc42 GTP-Binding Protein
By acting as a dynamic link between adjacent cells in a monolayer, adherens junctions (AJs) maintain the integrity of epithelial tissues while allowing for neighbor exchange. Although it is not currently understood how this combination of AJ stability and plasticity is achieved, junctionally associated actin filaments are likely to play a role, because actin-based structures have been implicated in AJ organization and in the regulation of junctional turnover.
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