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Publication Detail
PDGF/VEGF signaling controls cell size in Drosophila.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Sims D, Duchek P, Baum B
  • Publication date:
    2009
  • Pagination:
    R20, ?
  • Journal:
    Genome Biol
  • Volume:
    10
  • Issue:
    2
  • Country:
    England
  • PII:
    gb-2009-10-2-r20
  • Language:
    eng
  • Keywords:
    Animals, Autocrine Communication, Cell Line, Cell Size, Drosophila, Drosophila Proteins, Egg Proteins, Genomics, Neoplasms, Platelet-Derived Growth Factor, RNA Interference, RNA, Double-Stranded, Receptor Protein-Tyrosine Kinases, Signal Transduction, Vascular Endothelial Growth Factors
Abstract
In multicellular animals, cell size is controlled by a limited set of conserved intracellular signaling pathways, which when deregulated contribute to tumorigenesis by enabling cells to grow outside their usual niche. To delineate the pathways controlling this process, we screened a genome-scale, image-based Drosophila RNA interference dataset for double-stranded RNAs that reduce the average size of adherent S2R+ cells.
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