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Publication Detail
Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Liu T, Sims D, Baum B
  • Publication date:
    2009
  • Pagination:
    R26, ?
  • Journal:
    Genome Biol
  • Volume:
    10
  • Issue:
    3
  • Country:
    England
  • PII:
    gb-2009-10-3-r26
  • Language:
    eng
  • Keywords:
    Actins, Animals, Cell Line, Cell Shape, Cell Surface Extensions, Central Nervous System, Drosophila Proteins, Drosophila melanogaster, Gene Expression Profiling, Gene Expression Regulation, Genes, Insect, Genetic Testing, Hemocytes, Oligonucleotide Array Sequence Analysis, Organ Specificity, Phenotype, Protein-Serine-Threonine Kinases, RNA Interference
Abstract
In recent years RNAi screening has proven a powerful tool for dissecting gene functions in animal cells in culture. However, to date, most RNAi screens have been performed in a single cell line, and results then extrapolated across cell types and systems.
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