Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at http://www.ucl.ac.uk/finance/research/post_award/post_award_contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
The actin cytoskeleton in spindle assembly and positioning.
The most dramatic changes in eukaryotic cytoskeletal organization and dynamics occur during passage through mitosis. Although both spindle self-organization and actin-dependent cytokinesis have long been the subject of intense investigation, it has only recently become apparent that the actin cortex also has a key role during early mitosis. This is most striking in animal cells, in which changes in the actin cytoskeleton drive mitotic cell rounding and cortical stiffening. This mitotic cortex then functions as a foundation for spindle assembly and to guide spindle orientation with respect to extracellular chemical and mechanical cues. Here, we discuss this recent work and the possible role of crosstalk between the mitotic actin cortex and the plus ends of astral microtubules in this process.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
MRC/UCL Lab for Molecular Cell Bio
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by