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Publication Detail
APPLE‐Tree (Active Prevention in People at risk of dementia: Lifestyle, bEhaviour change and Technology to REducE cognitive and functional decline) programme: protocol
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Cooper C, Aguirre E, Barber JA, Bass N, Brodaty H, Burton A, Higgs P, Hunter R, Huntley J, Lang I, Kales HC, Marchant NL, Minihane AM, Ritchie K, Morgan-Trimmer S, Walker Z, Walters K, Wenborn J, Rapaport P, Minihane AM, Ritchie K, Morgan-Trimmer S, Walker Z, Walters K, Wenborn J, Rapaport P
  • Publisher:
    John Wiley and Sons
  • Publication date:
    23/12/2019
  • Journal:
    International Journal of Geriatric Psychiatry
  • Status:
    Published online
  • Country:
    England
  • Print ISSN:
    0885-6230
  • Language:
    eng
  • Keywords:
    Mild Cognitive Impairment, RCT, Subjective Cognitive Decline, dementia prevention
Abstract
BACKGROUND: Observational studies indicate that approximately a third of dementia cases are attributable to modifiable cardiometabolic, physical and mental health, social and lifestyle risk factors. There is evidence that intensive behaviour change interventions targeting these factors can reduce cognitive decline. METHODS AND ANALYSIS: We will design and test a low intensity, secondary dementia-prevention programme ('APPLE-Tree') to slow cognitive decline in people with Subjective Cognitive Decline with or without objective cognitive impairment. We will embed our work within social science research, to understand how dementia prevention is currently delivered and structured. We will carry out systematic reviews and around 50 qualitative interviews with stakeholders, using findings to co-produce the APPLE-Tree intervention. We plan a 10-session group intervention, involving personalised goal-setting, with individual sessions for those unable or unwilling to attend groups, delivered by psychology assistants who will be trained and supervised by clinical psychologists. The co-production group (including PPI (Public and Patient Involvement), academic and clinical/third sector professional representatives) will use the Behaviour Change Wheel Theoretical Framework to develop it. We will recruit and randomly allocate 704 participants, 1:1 to the intervention: informational control group. This sample size is sufficient to detect a between-group difference at 2 years of 0.15 on the primary outcome (cognition: modified Neuropsychological Test Battery; 90% power, 5% significance, effect size 0.25, standard deviation 0.6). DISSEMINATION: We will work with Public Health England and third sector partners to produce an effective national implementation approach, so that if our intervention works, it is used in practice. This article is protected by copyright. All rights reserved.
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