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Publication Detail
Spectral approach to time domain diffuse optical tomography for breast cancer: Validation on meat phantoms
  • Publication Type:
    Conference
  • Authors:
    Ferocino E, Di Sciacca G, Di Sieno L, Dalla Mora A, Pifferi A, Arridge S, Martelli F, Taroni P, Farina A
  • Publisher:
    SPIE
  • Publication date:
    11/07/2019
  • Published proceedings:
    Progress in Biomedical Optics and Imaging - Proceedings of SPIE
  • Volume:
    11074
  • ISBN-13:
    9781510628410
  • Status:
    Published
  • Name of conference:
    EUROPEAN CONFERENCES ON BIOMEDICAL OPTICS
  • Conference place:
    Munich, Germany
  • Conference start date:
    23/06/2019
  • Conference finish date:
    27/06/2019
  • Print ISSN:
    1605-7422
Abstract
© 2019 SPIE. Time Domain Diffuse Optical Tomography (TD-DOT) performed at multiple wavelengths can be used to non-invasively probe tissue composition. Then, tissue composition can be related to breast tissue and lesion type. Thus, TD-DOT could be used for therapy monitoring for breast cancer. We developed a software tool for multi-wavelength TD-DOT and performed a validation on meat phantoms to mimic tissue heterogeneity. An inclusion of different meat was exploited to mimic the presence of a lesion in the breast. Results show good localization of the inclusion, but poor quantification of the reconstructed breast composition. The use of a morphological prior constraint, providing information on inclusion geometry and position, significantly improves both localization and composition estimate.
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