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Publication Detail
The differentiation and engraftment potential of mouse hematopoietic stem cells is maintained after bio-electrospray.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Bartolovic K, Mongkoldhumrongkul N, Waddington SN, Jayasinghe SN, Howe SJ
  • Publication date:
  • Pagination:
    157, 164
  • Journal:
  • Volume:
  • Issue:
  • Status:
  • Country:
  • Language:
  • Keywords:
    Animals, Bone Marrow Cells, Cell Differentiation, Cell Separation, Female, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells, Mice
The bio-electrospray technique has been recently pioneered to manipulate living, immortalised and primary cells, including a wide range of stem cells. Studies have demonstrated that the creation of viable, fully functional in vitro microenvironments is possible using this technique. By modifying the bio-electrospray procedure (referred to as cell electrospinning), a variety of microenvironment morphologies have been fabricated. Because bio-electrospraying of biological material is a relatively new technique, it is important to determine if there are any unwanted consequences to the manipulated cells as a result of the procedure. Here, we establish the validity of the process using a heterogeneous, living population of hematopoietic stem/progenitor cells, using a functional in vitro assay and in vivo mouse model to investigate for side-effects that previous in vitro assays may not have detected. Our studies demonstrate that these bio-protocols have no obvious negative effects, thus indicating significant promise for utility in biological sciences and for a plethora of healthcare applications.
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