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Publication Detail
Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide
  • Publication Type:
    Working discussion paper
  • Authors:
    Michaels T, Šarić A, Curk S, Bernfur K, Arosio P, Meisl G, Dear A, Cohen S, Vendruscolo M, Dobson C, Linse S, Knowles T
  • Publication date:
    11/01/2020
  • Status:
    Published
Abstract
Oligomeric aggregates populated during the aggregation of the A β 42 peptide have been identified as potent cytotoxins linked to Alzheimer’s disease, but the fundamental molecular pathways that control their dynamics have yet to be elucidated. By developing a general approach combining theory, experiment, and simulation, we reveal in molecular detail the mechanisms of A β 42 oligomer dynamics during amyloid fibril formation. Even though all mature amyloid fibrils must originate as oligomers, we find that most A β 42 oligomers dissociate to their monomeric precursors without forming new fibrils. Only a minority of oligomers converts into fibrillar species. Moreover, the heterogeneous ensemble of oligomeric species interconverts on timescales comparable to aggregation. Our results identify fundamentally new steps that could be targeted by therapeutic interventions designed to combat protein misfolding diseases.
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