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Publication Detail
Switch junction sequences in PMS2-deficient mice reveal a microhomology- mediated mechanism of Ig class switch recombination
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Ehrenstein MR, Rada C, Jones AM, Milstein C, Neuberger MS
  • Publication date:
  • Pagination:
    14553, 14558
  • Journal:
    Proceedings of the National Academy of Sciences of the United States of America
  • Volume:
  • Issue:
  • Print ISSN:
  • Keywords:
    Adenosinetriphosphatase, Affect, Animal, Base Pair Mismatch, Base Sequence, Class, class switching, deficiency, DELETION, difference, DNA, DNA binding, DNA Binding Proteins, DNA Repair, DNA-binding, DNA-Binding Proteins, EC, END, genetics, HOMOLOGY, IM, Immunoglobulin Class Switching, JUNCTIONS, LA, mammalian, May, MECHANICS, MECHANISM, mice, Mice, Knockout, Molecular Sequence Data, MSH2, Mutation, Nucleotide, PATHWAY, PATHWAYS, Pattern, process, processes, PROTEIN, Proteins, Proto Oncogene Proteins, Proto-Oncogene Proteins, Recombination, RESOLUTION, SEQUENCE, Sequence Homology, Nucleic Acid, SEQUENCES, STATE, STATES, SUBSTITUTION, Support, Non-U.S.Gov't, SWITCH, united, United States, UNITED-STATES
  • Notes:
    UI - 21592955 LA - eng RN - 0 (DNA-Binding Proteins) RN - 0 (MSH2 protein, mammalian) RN - 0 (Proto-Oncogene Proteins) RN - 9007-49-2 (DNA) RN - EC 3.6.1.- (hPMS2 protein) RN - EC (Adenosinetriphosphatase) PT - Journal Article DA - 20011205 IS - 0027-8424 SB - IM CY - United States
Isotype switching involves a region-specific, nonhomologous recombinational deletion that has been suggested to occur by nonhomologous joining of broken DNA ends. Here, we find increased donor/acceptor homology at switch junctions from PMS2-deficient mice and propose that class switching can occur by microhomology-mediated end-joining. Interestingly, although isotype switching and somatic hypermutation show many parallels, we confirm that PMS2 deficiency has no major effect on the pattern of nucleotide substitutions generated during somatic hypermutation. This finding is in contrast to MSH2 deficiency. With MSH2, the altered pattern of switch recombination and hypermutation suggests parallels in the mechanics of the two processes, whereas the fact that PMS2 deficiency affects only switch recombination may reflect differences in the pathways of break resolution
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