Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Gap junctions in the stria vascularis and effects of ethacrynic acid.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Forge A
  • Publication date:
  • Pagination:
    189, 200
  • Journal:
    Hear Res
  • Volume:
  • Issue:
  • Status:
  • Country:
  • Print ISSN:
  • PII:
  • Language:
  • Keywords:
    Animals, Cochlea, Ethacrynic Acid, Freeze Fracturing, Guinea Pigs, Intercellular Junctions, Microscopy, Electron, Stria Vascularis
Gap junctions in the stria vascularis of guinea pigs were studied using freeze-fracture. Nearly all junctions were associated with basal cells. They were present between basal cells and spiral ligament cells, adjacent basal cells, basal and marginal cells and basal and intermediate cells. Following administration of ethacrynic acid, gap junction morphology altered. There was a statistically significant decrease in the centre-to-centre spacing of gap junction subunits and the subunits became regularly packed. Such changes were distinct before any other gross morphological change in the stria had occurred. These morphological alterations suggest that physiological uncoupling of stria cells may occur in response to the effects of ethacrynic acid.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
The Ear Institute
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by